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In mice, 1P-LSD produces LSD-like effects with 38% the potency of LSD and it is therefore classed as a serotonergic hallucinogen. However, 1P-LSD itself is unable to bind to the serotonergic 5-HT2A receptors. But since LSD is detected when 1P-LSD is incubated in human serum, 1P-LSD may act, at least in part, as a prodrug for LSD.
Prior to the publishing of the above-cited research, pharmacologist David E. Nichols reportedly commented with his thoughts on 1P-LSD serotonin receptor binding:
On the periodic table, homologous elements share many electrochemical properties and appear in the same group (column) of the table. For example, all noble gases are colorless, monatomic gases with very low reactivity. These similarities are due to similar structures in their outer shells of valence electrons. Mendeleev used the prefix eka- for an unknown element below a known one in the same group.
1P-LSD on blotter paper
The effects profile of 1P-LSD is not well defined in the scientific literature. It is generally thought to be comparable to that of LSD. Many anecdotal reports indicate that 1P-LSD has a slightly shorter duration than LSD in humans, with the majority of users stating that they cannot distinguish the qualitative effects of 1P-LSD from LSD.
Psychedelics are a class of drugs whose primary action is to trigger psychedelic experiences via serotonin receptor agonism, causing thought and visual/auditory changes, an altered state of consciousness. Major psychedelic drugs include mescaline, LSD, psilocybin, and DMT. Studies show that psychedelics are physiologically safe and do not lead to addiction. Studies conducted using psilocybin in a psychotherapeutic setting reveal that psychedelic drugs may assist with treating alcohol and nicotine addiction.